Little Devices, Big Ideas

MIT News covers our new Ampli Plug-and-Play diagnostic platform today. Click above to read the feature.

We develop empowerment technologies for health. We believe that innovation and design happens at the frontline of healthcare where providers and patients can invent everyday technologies to improve outcomes. By radically democratizing the tools of medical creation, we seek to enable front line patients and providers to invent answers to disease burdens.

Research

Ampli: Construction Sets for Paperfluidics and Diagnostics


We developed Ampli diagnostic blocks after realizing that most paper diagnostics, while simple, were still subject to a lot of black box engineering. This renders the technology difficult to fabricate in low resource areas (where they stand to benefit the most). So we thought of the way electronics democratized fabrication by adopting breadboards where components enjoy hand placed modularity. No machining, special instruments or even hand dexterity is required to create a paperfluidic circuit. Biochemistry doesn’t have a breadboard, so we made one. Our goal was to create a plug and play set of blocks that could form, stop and modify reactions in real time. In glassware or microfluidics, this is almost impossible to do (the stopping and changing your mind part). Modular paper allows us to do that.

In our paper published in Advanced Healthcare Materials, we demonstrate our system with useful diagnostics for human health ranging from elemental glucose assays and infection diagnostics, to multiplexed peptide reporter cancer test and viral immunoassays. It was important to us that this worked with real reaction and not colored dyes because that can be a valley of death in the development of these systems.

While we are excited about lowering biofabrication barriers, we also discovered new forms of immunoassay enhancements not feasible in traditional systems, such as dynamically changing the direction of flow on paper, which leads to an substantially increased diagnostic signal. This will be particularly useful for “bloodless assays” for disease: saliva, sweat, water, or urine biomarkers where it’s easy to get a sample (no blood) but it’s the sample is very diluted. Some targets are HIV, cancer biomakers, and viruses like Zika where the levels of the disease are not high but still dangerous. Without external equipment, such as centrifuges, this is not possible with traditional paper diagnostic tests.

MEDIKit: DIY Technologies for Health

The core impact of this project stems from developing the design kits as a platform technology. Modular components allow medical professionals to design their own appropriate solutions that are more useful and sustainable to physicians and patients. Given the appropriate tools and the right context set by the course, MEDIKit users are empowered to innovate and address the unique challenges in their work environment.

The MEDIKits span six areas of technology: drug delivery, diagnostics, microfluidics, prosthetics, vital signs and surgical devices. The kits contain a combination of medical device parts coded with a language of design, platform technologies that can be adapted, such as handheld microscopes, and materials to build and modify devices.

Our research into user-enabled medical prototyping continues at the lab. We are keenly interested in understanding the effects of shifting the power from the { expert + regulator } and sharing it with everyday { doctors + nurses + users } to make more transparent and accessible designs.

Viral Diagnostics

In collaboration with Gehrke Lab at MIT IMES and the Hammad-Schifferly group at UMass Boston, we are developing a series of multiplexed diagnostics for fever viruses such as dengue, ebola, zika and chikungunya. View our newest paper in the September 2017 Issue of Science Translational Medicine.

 

 

 

 

Open Access Diagnostics

 

 

 

 

 

 

 

Rapid diagnostic fabrication can be obscure in lab practice and may involve expensive biological assays and methods. We are create an open access distribution of our diagnostic devices so that anyone, anywhere in the world with access and the need for patient care can develop their own paper devices.

Our People

Jose Gomez-Marquez, co-director
Anna K. Young, co-director
Nikolas Albarran, Senior Engineer

 

 

Zuly Mama, BioEng
Caroline Lang, Biology
Lydia Light, MechE

 

Riana Hoagland, BioEng
Jonah Butler, ChemE
Kate Pundyk, PoliSci

 

 

 

 

 

 

 

 

 

 

 

Max-Philipp Schrader, CS TU München Exchange

 

 

 

 

 

 

Alumni

Chew Chai ’17 –  PhD program at Stanford
Natzem Lima ’16, Amazon
Ivy Chang – Course 2, MIT
Elizabeth Phillips ’13, – Graduate Bioengineering Purdue
Charles Hsu, ’12 – Yale School of Medicine
Katie Creasy, ’11 – Stanford
Paul Hlebowitsh , ’11 – Tive
[full list soon!]

 

 

 

 

 

Jose Gomez-Marquez

Jose directs the Little Devices Lab and is the creator of MIT’s first course on affordable medical device hardware.  His group’s MEDIKit platform, a series of design building blocks that empower doctors and nurses in developing countries to invent their own medical technologies. His other research projects include inhalable vaccine technology, crowdsourced diagnostics, paper microfluidics, and affordable diagnostics for extreme environments. 

Jose has served on the European Union’s Science Against Poverty Taskforce and has participated as an expert advisor in the President’s Council of Advisors on Science and Technology. Jose is a 3 time MIT IDEAS Competition winner, including two Lemelson Awards for International Technology.

In 2009, he was selected to Technology Review’s T35, which also named him Humanitarian of the Year. In 2011 he was named a TED Fellow. He arrived to the United States from his native Honduras on a Rotary scholarship and currently lives in Cambridge, Massachusetts.

 

Anna Young

Anna graduated from the University of Dayton with a Bachelors degree in Finance and Economics in 2008. Anna coordinated projects in Nicaragua, Ecuador and Ethiopia and developed strategies to move technologies from need identification, to R&D, to field testing and user feedback and then implementation. Her main responsibilities included management of the MEDIKit project, the group solar autoclave research, and the HST.426 MakerLab course at MIT. Her solar autoclave research was recently recognized by the WHO as one of the top 6 innovative technologies in health. Anna is co-founder of Salud del Sol, a social enterprise focused on solar technologies for health operating in Nicaragua and was an R&D Officer for International Laboratories of Innovations in International Health at MIT.

 

 

Nikolas Albarran

Nikolas Albarran is a senior engineer at Little Devices where he is responsible for managing the rapid prototyping capacity in the MakerNurse initiative and operations for the MakerHealth makerspace network. Through these units, he established the first American medical makerspace in a hospital to enable rapid prototyping near the bedside. He is a guest lecturer in MIT HST’s Maker Lab class, aimed at medical prototyping and clinical co-design for devices. Nik is a graduate MIT’s Mechanical Engineering department with a specialization in product design.

 

 

Teaching at MIT

HST 426
Maker Lab: Creating Technologies to Re-invent Health Care

Term: Spring

Course Director(s):Lee Gehrke,  Jose Gomez-Marquez,  Anna Young

Time: Lecture: Tu 2:30-3:30pm; Lab: Th 2:00-5:00pm

Location:  Lecture: E25-117; Lab: E25-101 and E25-533

Course Website: makerlab.mit.edu

Prerequisite: None
Restrictions: Undergraduate course; Graduate students eligible with permission of instructor

MIT Units: 

1-3-8 (N-Level Credit )

Harvard Units: 

Unknown
The course will use and design do-it-yourself medical technologies, creative biosensors and health construction kits to create accessible, patient centered solutions. Will cover affordable prototyping and design strategies for health and medicine that can be applied in the American healthcare system and in low resource settings. Successful projects will create patient-generated data devices as a learning model, and students will design affordable devices that are used by patients to manage their health. Using Construction Sets for Health as a strategy, we will explore the rich diversity of possibilities created when patients are empowered to design their own solutions. Hands-on weekly labs will include paper diagnostics, microcontroller applications, wearable sensors, mobile health app design and health kit architectures.